Oncology Panels

Primary care clinicians work on the front line where advances in genetic research can be directly applied to patient care.

The MassARRAY® System. Highly accurate, sensitive analysis for cancer research.

The utility of somatic mutations, translocations, and gene gain or loss in cancer research is well accepted and widely documented. Genetic and somatic mutations can be employed to study their effect on oncogenesis, disease progression, or therapeutic response. Mutations play a key role as biomarkers for risk, progression, and prognosis.

The MassARRAY System offers:

  • A highly sensitive method for interrogating heterogeneous tumor samples and cell line DNA.
  • Rapid assay design for mutation analysis, methylation, and gene transcript or copy number analysis.
  • A targeted screening approach to validate relevant biomarkers.
  • A high-throughput method to confirm or replicate data from genome wide studies, sequencing, and clinical research.
  • Rapid conversion of validated information into clinical assays.

Cancer Research using the MassARRAY System.

The MassARRAY System’s MALDI-TOF mass spectrometry technology, in combination with the relevant reagent sets and software, offers high value tools for cancer research. You can readily design custom panels for genotyping, somatic mutation profiling, gene expression, and methylation, or select from a growing number of predesigned panels to aide in your clinical and translational research efforts.

The MassARRAY System has been used by a number of leading cancer research institutes to design custom panels—such as the OncoMap panel—and reliably detect as little as 5-10% mutant alleles within mixed, heterogeneous tumor samples [Nat Genet. 2007 Mar;39(3):347-51].

It can also be used to interrogate tens and hundreds of mutations in a rapid, multiplexed assay format. Mutation screening may be relevant for clinical research to evaluate potential targeted therapies in cancer.

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